The 2-Minute Rule for thr77 login
The 2-Minute Rule for thr77 login
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The antibody is from purified rabbit serum by affinity purification through sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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Overexpression of this gene has long been observed in lots of tumors, which leads to chromosome instability, and thus could contribute to tumorigenesis. This protein was observed to affiliate with, and become involved in, the phosphorylation of NPAT protein (nuclear protein mapped for the ATM locus), which participates in cell-cycle regulated histone gene expression and performs a important role in marketing cell-cycle progression inside the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode unique isoforms, are already explained. Two added splice variants ended up documented but thorough nucleotide sequence facts will not be nevertheless readily available.
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Blocking peptides are peptides that bind specifically to your goal antibody and block antibody binding. These peptide usually has the epitope acknowledged via the antibody.
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This guide outlines even further feasible optimization of mobile and immunoassay parameters to make sure the very best final results are...
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This guide outlines more doable optimization of mobile and immunoassay parameters to make sure the absolute best effects are...
Antibodies sure to the blocking peptide now not bind get more info towards the epitope within the goal protein. By comparing the staining from your blocked antibody as opposed to the antibody by yourself, one can see which staining is certain.
Goal Details Cyclin E belongs on the hugely conserved cyclin household, whose associates are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Distinctive cyclins exhibit distinct expression and degradation styles which lead towards the temporal coordination of each and every mitotic function. Cyclin E types a posh with and features as a regulatory subunit of CDK2, whose exercise is required for mobile cycle G1/S transition. This protein accumulates for the G1-S phase boundary which is degraded as cells progress as a result of S stage.
The measurement of protein phosphorylation is a useful tool for measuring the modulation of receptor activation by equally antibodies...
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